The hosts enter the two-match series with renewed confidence after securing a 1-0 series win over Sri Lanka, their first win of the current WTC cycle. Meanwhile, Pakistan have struggled in recent months, losing three consecutive Tests after starting their campaign with a win over South Africa.
Babar Azam returns as captain after replacing Shan Masood, whose side have lost 12 of their 16 Tests in charge. Babar also enjoyed an encouraging surge, scoring a century against a West Indies Select XI, while opener Azan Awais hit a hundred and returning pacer Mohammad Ali claimed a five-wicket haul.
Pakistan were forced into a change after opener Abdullah Fazal was ruled out with a back injury. Imam-ul-Haq returns to partner Awais at the top, while slow left-arm spinner Ali Usman makes his Test debut ahead of the experienced Sajid Khan.
West Indies have named a heavy pace attack featuring Kemar Roach, Shamar Joseph and Jayden Seales, with Jomel Warrican as the lone specialist spinner after Alzarri Joseph withdrew from the series.
The match also marks the first Test hosted at the Brian Lara Cricket Academy, the 13th Caribbean Test.